Ubilon Tablet 2.5 mg contains Tibolone, a synthetic steroid used in postmenopausal women to relieve menopausal symptoms and to help prevent osteoporosis in those at high risk of fractures who cannot use other osteoporosis treatments. Tibolone has estrogenic, progestagenic, and androgenic properties, making it effective in managing a wide range of menopausal concerns.

Indications

• Treatment of symptoms associated with natural or surgical menopause in postmenopausal women

• Prevention of osteoporosis in postmenopausal women at high risk of fractures who are unable to take other osteoporosis-preventive medicines

Pharmacology

Tibolone is rapidly metabolized after oral administration into three active metabolites. Two metabolites (3α-OH and 3β-OH) exert predominantly estrogenic effects, while the δ4-isomer and the parent compound have progestagenic and androgenic activity.
Ubilon compensates for reduced estrogen levels in postmenopausal women, helping to alleviate hot flushes, vaginal dryness, and vaginal atrophy. It also prevents bone loss following menopause or ovariectomy and may have beneficial effects on mood and libido.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage & Administration

• Recommended dose: One tablet (2.5 mg) once daily

• Swallow the tablet with water, preferably at the same time each day

• Symptom improvement usually begins within a few weeks; optimal benefits are seen after at least 3 months of continuous therapy

Initiation of therapy

• Natural menopause: Start at least 12 months after the last natural menstrual period

• Surgical menopause: Treatment may begin immediately

• Switching from sequential HRT: Start Ubilon the day after completing the previous regimen

• Switching from continuous-combined HRT: Start at any time

Missed dose

• Take as soon as remembered unless more than 12 hours have passed

• If more than 12 hours overdue, skip the missed dose and continue as scheduled

• Missing doses may increase the risk of breakthrough bleeding or spotting

Drug Interactions

• Enzyme-inducing drugs such as barbiturates, carbamazepine, hydantoins, and rifampicin may reduce the effectiveness of Ubilon

• Ubilon may enhance the effects of anticoagulants due to increased fibrinolytic activity

Contraindications

• Pregnancy and lactation

• Known or suspected hormone-dependent tumors

• Cardiovascular or cerebrovascular disorders

• Active or past deep vein thrombosis or thromboembolic disorders

• Vaginal bleeding of unknown cause

• Severe liver disease

Side Effects

• Vaginal bleeding or spotting, especially during initial months of therapy

• Headache, migraine

• Oedema, dizziness

• Pruritus, rash

• Weight gain

• Nausea, abdominal pain

• Depression

Pregnancy & Lactation

Ubilon Tablet is contraindicated during pregnancy and breastfeeding. If pregnancy occurs during treatment, therapy should be discontinued immediately.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions & Warnings

Use with caution in patients with:

• Renal dysfunction

• History of liver disease

• Epilepsy or migraine

• Hypercholesterolemia

• Diabetes mellitus or impaired carbohydrate metabolism

• History of cholestatic jaundice

Overdose

Acute toxicity is very low. Possible symptoms include nausea, vomiting, or withdrawal bleeding. Treatment is symptomatic and supportive.

Therapeutic Class

Drugs for menopausal symptoms: Hormone replacement therapy

Storage Conditions

Store in a cool and dry place. Protect from light. Keep out of reach of children.