Ultrapime Injection 2 gm/vial contains Cefepime Hydrochloride, a fourth-generation cephalosporin antibiotic used for the treatment of severe and complicated bacterial infections caused by susceptible microorganisms. This injectable antibiotic provides broad-spectrum activity against Gram-positive and Gram-negative bacteria, including strains resistant to third-generation cephalosporins.

Cefepime, the active ingredient in Ultrapime Injection, is particularly effective in hospital-acquired infections, complicated community-acquired infections, and life-threatening conditions such as septicemia, pneumonia, complicated urinary tract infections, intra-abdominal infections, and febrile neutropenia. Its parenteral administration ensures rapid systemic availability and high tissue concentrations, essential for critically ill patients requiring immediate and effective therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

The 2 gm vial strength allows for higher dosing, necessary in severe infections, particularly those caused by Pseudomonas aeruginosa, Enterobacter spp., Escherichia coli, Klebsiella pneumoniae, and other resistant bacteria. Ultrapime Injection 2 gm/vial is suitable for intravenous administration, providing fast therapeutic response and improved clinical outcomes.

Therapeutic Class

Fourth-generation Cephalosporin – Parenteral Antibiotic

Indications

Ultrapime Injection 2 gm/vial is indicated for the treatment of:

• Severe lower respiratory tract infections: Community-acquired and hospital-acquired pneumonia

• Complicated urinary tract infections and pyelonephritis

• Skin and soft tissue infections caused by susceptible bacteria

• Intra-abdominal infections: Administered in combination with metronidazole

• Septicemia and bacteremia requiring immediate systemic therapy

• Febrile neutropenia in immunocompromised patients

This formulation is highly effective against bacteria producing beta-lactamases and multidrug-resistant organisms commonly encountered in hospital settings.

Pharmacology

Cefepime Hydrochloride is a beta-lactam antibiotic that exerts bactericidal effects by binding to penicillin-binding proteins (PBPs), inhibiting bacterial cell wall synthesis, and leading to cell lysis.

Pharmacokinetics:

• Administration: IV or IM

• Distribution: Widely distributed in body tissues and fluids, including lungs, kidneys, bile, and intra-abdominal sites

• Excretion: Approximately 85% excreted unchanged in urine

• Half-life: About 2 hours in patients with normal renal function

• Broad-spectrum activity: Effective against both Gram-positive and Gram-negative pathogens, including resistant strains

Mode of Action

• Inhibits bacterial cell wall synthesis by binding to PBPs

• Leads to bacterial lysis and death

• Provides rapid bactericidal activity for systemic infections

Dosage and Administration

Adults:

• Severe infections: 2 gm IV every 8–12 hours, depending on infection severity and renal function

Pediatric Patients:

• Dose is weight-based and adjusted according to infection type

• Typical dose: 50 mg/kg IV every 12 hours for moderate infections; may increase for severe infections

Renal Impairment:

• Dose adjustment is required for patients with creatinine clearance <60 mL/min

• Prevents accumulation and reduces the risk of neurotoxicity

Administration Notes:

• Reconstitute with sterile water for injection, 0.9% sodium chloride, or 5% dextrose

• Administer IV slowly over 3–5 minutes or via infusion over 30 minutes

• IM administration is possible if necessary, avoiding intradermal injection

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Known hypersensitivity to cefepime, other cephalosporins, or beta-lactam antibiotics

• History of severe anaphylactic reaction to penicillin

Side Effects

• Gastrointestinal: nausea, vomiting, diarrhea

• Injection site reactions: pain, redness, inflammation

• Rare: rash, urticaria, fever, neurotoxicity (especially in renal impairment), Clostridium difficile-associated diarrhea

Precautions and Warnings

• Monitor renal function and adjust dose as needed

• Observe for signs of superinfection or Clostridium difficile infection

• Caution in patients with penicillin allergy

• Monitor hematologic and hepatic function during prolonged therapy

Pregnancy and Lactation

• Pregnancy Category B: Use only if clearly indicated

• Cefepime is excreted in breast milk; caution is advised in nursing mothers

Storage Conditions

• Store at 20–25°C in a dry place, away from light

• Keep out of reach of children

• Reconstituted solution should be used immediately or stored under recommended conditions.