Valex CR Tablet 300 mg is a controlled-release formulation of Sodium Valproate, designed for the management of epilepsy, bipolar disorder, and migraine prophylaxis. The controlled-release (CR) mechanism ensures sustained drug delivery, maintaining steady plasma levels, reducing the frequency of dosing, and minimizing gastrointestinal side effects often associated with immediate-release formulations.

Valex CR Tablet 300 mg is effective in controlling all types of seizures, including partial, generalized tonic-clonic, absence, myoclonic, and atonic seizures, making it suitable for both adults and pediatric patients over 2 years of age. It is also indicated for prophylaxis of febrile convulsions and post-traumatic epilepsy, as well as bipolar disorder and migraine prevention.

The drug works by enhancing gamma-aminobutyric acid (GABA) levels in the brain, which helps stabilize neuronal firing and reduce abnormal electrical activity responsible for seizures.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Primary Anti-Epileptic Drugs

Indications

Valex CR Tablet 300 mg is indicated for:

• All types of epilepsy:

  • Partial seizures

  • Generalized tonic-clonic seizures (grand mal)

  • Absence seizures (petit mal)

  • Myoclonic and atonic seizures

  • Mixed seizures including absence attacks

• Prophylaxis of febrile convulsions

• Prophylaxis of post-traumatic epilepsy

• Bipolar disorder (mood stabilization)

• Prophylaxis of migraine

Pharmacology

Sodium Valproate in Valex CR Tablet increases GABA concentrations in the central nervous system, enhancing inhibitory neurotransmission and stabilizing neuronal activity. This mechanism reduces seizure frequency and intensity.

Pharmacokinetics of CR formulation:

• Slow and sustained absorption, providing stable plasma levels

• Reduced peak-trough fluctuations compared to immediate-release tablets

• Metabolized in the liver; partially excreted in urine

• Half-life: 9–16 hours, allowing once- or twice-daily dosing

Dosage and Administration

Adults:

• Initial dose: 600 mg/day in divided doses (preferably after food)

• Titration: Increase by 200 mg/day at 3-day intervals as required

• Maintenance dose: 1–2 g/day, divided doses (20–30 mg/kg/day)

Children (up to 20 kg):

• Initial dose: 20 mg/kg/day, divided doses

• Titrated according to clinical response and plasma levels

Children (over 20 kg):

• Initial dose: 400 mg/day, increased to 20–30 mg/kg/day as needed

Bipolar disorder:

• Initially 600 mg/day, maintenance 1–2 g/day in divided doses

Migraine prophylaxis:

• 400–600 mg/day, may require up to 1–1.5 g/day

Important:

• Swallow tablets whole; do not crush or chew

• Administer after food to minimize gastrointestinal discomfort

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Hypersensitivity to Sodium Valproate

• Liver dysfunction or severe hepatic impairment

• Pregnancy, especially during the first trimester, unless clearly indicated

Side Effects

Common side effects:

• Gastrointestinal: nausea, vomiting, anorexia

• CNS: sedation, tremor, ataxia

• Dermatologic: rash, alopecia

• Rare but serious: hepatotoxicity, pancreatitis, hyperammonemia

Monitoring of liver function, plasma levels, and coagulation parameters is recommended, particularly in children under 2 years or patients on multiple antiepileptics.

Precautions

• Avoid abrupt discontinuation to prevent seizure recurrence

• Adjust dose in renal impairment

• Careful monitoring in systemic lupus erythematosus, pregnancy, and breastfeeding

• May interfere with urine ketone tests

Pregnancy and Lactation

• Crosses the placenta; exposure in the first trimester may lead to neural tube defects

• Excreted in breast milk; caution advised

Storage

• Store below 30°C, protected from light

• Keep out of reach of children

Mode of Action

Valex CR Tablet 300 mg enhances GABAergic neurotransmission, stabilizing neuronal excitability and controlling seizures across multiple types. The controlled-release formulation ensures prolonged therapeutic effect with fewer daily doses, improving patient compliance.