Verquv Tablet 2.5 mg contains Vericiguat, a soluble guanylate cyclase (sGC) stimulator used for the management of chronic heart failure (HF). It is particularly beneficial for patients with reduced ejection fraction (HFrEF) who remain symptomatic despite standard heart failure therapies. Vericiguat works by enhancing the nitric oxide–sGC–cGMP pathway, leading to vasodilation, improved cardiac function, and reduced cardiac stress.

Verquv is an oral once-daily therapy that helps reduce the risk of cardiovascular death and heart failure hospitalization, improving patient quality of life and exercise tolerance.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Verquv Tablet 2.5 mg is indicated for:

• Chronic heart failure with reduced ejection fraction (HFrEF)
• Patients with persistent symptoms despite optimized guideline-directed medical therapy
• Reducing the risk of heart failure hospitalization and cardiovascular death

Mechanism of Action

Vericiguat acts as a soluble guanylate cyclase stimulator:

• Enhances the activity of sGC, a key enzyme in the nitric oxide (NO) signaling pathway
• Increases levels of cyclic guanosine monophosphate (cGMP)
• Promotes vasodilation and relaxation of blood vessels
• Reduces cardiac preload and afterload, improving left ventricular function
• Helps counteract cardiac remodeling and progression of heart failure

By targeting the NO–sGC–cGMP pathway, Vericiguat complements other heart failure therapies for comprehensive management.

Dosage and Administration

• Recommended starting dose: 2.5 mg once daily, orally
• Dose may be titrated based on patient tolerance and clinical response
• Can be taken with or without food
• Swallow the tablet whole with a full glass of water
• Regular monitoring of blood pressure and kidney function is recommended during therapy

Benefits

• Reduces risk of cardiovascular death and heart failure hospitalization
• Improves exercise tolerance and symptomatic control in chronic HFrEF
• Oral, once-daily dosing enhances treatment adherence
• Complements standard heart failure therapies such as ACE inhibitors, beta-blockers, and diuretics
• Supports long-term cardiac function preservation

Side Effects

Common side effects may include:

• Dizziness or lightheadedness (especially on standing)
• Low blood pressure (hypotension)
• Headache
• Fatigue

Rare but serious side effects:

• Severe hypotension
• Syncope (fainting)
• Allergic reactions (rash, swelling, difficulty breathing)

Seek immediate medical attention if serious or persistent symptoms occur.

Precautions and Warnings

• Use with caution in patients with hypotension, severe renal impairment, or hepatic impairment
• Avoid concomitant use with nitrates or other nitric oxide donors, as it may cause severe hypotension
• Pregnancy and breastfeeding: only use if clearly indicated by a physician
• Regular monitoring of renal function, electrolytes, and blood pressure is advised
• Do not abruptly discontinue therapy without medical advice

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Vericiguat may interact with:

• Nitrates or nitric oxide donors (risk of severe hypotension)
• PDE5 inhibitors (may lower blood pressure significantly)
• Drugs affecting renal or hepatic clearance

Always inform your healthcare provider about all medications and supplements before starting therapy.

Storage

• Store below 30°C in a dry, cool place
• Protect from light and moisture
• Keep out of reach of children
• Do not use after the expiration date.