Xaloplat Injection 5 mg/ml contains Oxaliplatin, a platinum-based chemotherapy agent used in the treatment of certain types of cancer, particularly colorectal cancer. It is administered intravenously under the supervision of qualified healthcare professionals and is commonly used in combination with other anticancer medicines as part of combination chemotherapy regimens. Oxaliplatin works by interfering with cancer cell growth and division, helping to slow or stop the spread of tumors.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Xaloplat Injection is indicated for:

• Treatment of metastatic colorectal cancer
• Adjuvant treatment of stage III colon cancer following surgical resection
• Use in combination with fluorouracil (5-FU) and leucovorin (FOLFOX regimen)
• Other malignancies as determined by an oncologist

Mechanism of Action

Oxaliplatin exerts its anticancer effects by forming cross-links within and between DNA strands in cancer cells. This disrupts DNA replication and transcription, ultimately leading to cell cycle arrest and programmed cell death (apoptosis). Its activity is particularly effective against rapidly dividing cancer cells.

Dosage and Administration

• Administered intravenously as an infusion by a trained healthcare professional
• Dosage is based on body surface area (BSA), patient condition, and treatment protocol
• Typically given every 2 weeks as part of combination chemotherapy
• Infusion should be administered over 2–6 hours depending on regimen
• Adequate hydration and monitoring are required during treatment

Benefits

• Effective in treating colorectal cancer, especially in combination therapy
• Helps reduce tumor size and slow disease progression
• Improves survival rates in adjuvant and metastatic settings
• Well-established role in standard chemotherapy regimens

Side Effects

Common side effects include:

• Nausea and vomiting
• Diarrhea
• Fatigue and कमजोरी
• Peripheral neuropathy (tingling, numbness in hands and feet)
• Decreased blood cell counts (anemia, neutropenia, thrombocytopenia)

Serious side effects:

• Severe allergic reactions
• Persistent neuropathy
• Bone marrow suppression
• Liver function abnormalities

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use under strict medical supervision in a clinical setting
• Monitor blood counts regularly during treatment
• Avoid exposure to cold temperatures, which may worsen neuropathy
• Use cautiously in patients with kidney or liver impairment
• Not recommended during pregnancy; effective contraception is required during treatment
• Inform the doctor about all medications and medical history

Storage

• Store as per manufacturer guidelines, typically between 2°C to 8°C
• Protect from light
• Do not freeze
• Keep out of reach of children.