Zopanib Tablet 400 mg contains Pazopanib Hydrochloride, an oral targeted anticancer medicine belonging to the tyrosine kinase inhibitor (TKI) class. It is used in the management of certain advanced cancers by blocking multiple signaling pathways responsible for tumor growth and blood vessel formation. This higher-strength formulation is commonly used in patients requiring standard or intensified dosing under strict oncology supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Zopanib Tablet is indicated for:

• Advanced renal cell carcinoma (kidney cancer)
• Advanced soft tissue sarcoma after prior chemotherapy
• Other advanced solid tumors as determined by an oncologist

Mechanism of Action

Pazopanib works by inhibiting several receptor tyrosine kinases, including VEGFR, PDGFR, and c-KIT. Through this action:

• It blocks tumor angiogenesis (formation of new blood vessels that feed tumors)
• It reduces tumor cell proliferation and survival
• It helps slow cancer progression and metastatic spread

Dosage and Administration

• Dosage is determined by an oncologist based on clinical condition
• Usually taken once daily
• Must be taken on an empty stomach (at least 1 hour before or 2 hours after food)
• Swallow tablet whole with water; do not crush or chew
• Treatment is continued as long as there is clinical benefit and tolerability

Benefits

• Targeted therapy for advanced cancers
• Helps inhibit tumor growth and angiogenesis
• Oral administration for convenient long-term use
• Slows disease progression in renal cell carcinoma and soft tissue sarcoma
• Improves disease control in selected patients

Side Effects

Common side effects may include:

• Diarrhea
• Fatigue
• Nausea or vomiting
• Loss of appetite
• High blood pressure
• Hair color changes

Serious side effects:

• Liver toxicity (elevated liver enzymes)
• Cardiovascular effects
• Severe hypertension
• Bleeding or thrombotic events
• QT interval prolongation (rare)

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use only under specialist oncology supervision
• Regular monitoring of liver function and blood pressure is required
• Not recommended in severe liver impairment
• Avoid during pregnancy and breastfeeding
• Use cautiously in patients with cardiac disease
• Inform physician about all medications due to interaction risk

Storage

• Store below 25°C
• Protect from moisture and light
• Keep tightly closed
• Keep out of reach of children.