A-Fenac Tablet 25 mg contains Diclofenac Sodium, a well-established nonsteroidal anti-inflammatory drug (NSAID) used for its analgesic, anti-inflammatory, and antipyretic properties. It is effective in relieving mild to moderate pain and reducing inflammation in a wide range of acute and chronic conditions affecting the musculoskeletal system. The 25 mg strength is particularly suitable for initial therapy, mild pain, or patients who require lower doses.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

A-Fenac Tablet 25 mg is indicated for the relief of pain and inflammation associated with:

• Rheumatoid arthritis

• Osteoarthritis

• Ankylosing spondylitis

• Acute musculoskeletal pain

• Low back pain

• Dental pain

• Post-operative and post-traumatic pain

• Dysmenorrhea

• Soft tissue injuries such as sprains and strains

It helps improve mobility and quality of life by reducing pain and swelling.

Therapeutic Class

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Pharmacology

Diclofenac Sodium works by inhibiting the cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins play a key role in mediating pain, inflammation, and fever. By reducing prostaglandin production, diclofenac effectively decreases inflammation, alleviates pain, and lowers fever.

After oral administration, diclofenac is rapidly absorbed from the gastrointestinal tract. It undergoes first-pass metabolism in the liver and is widely distributed to body tissues, particularly inflamed areas. Diclofenac is extensively bound to plasma proteins and is eliminated through renal and biliary pathways.

Mode of Action

A-Fenac Tablet 25 mg reduces pain and inflammation by blocking prostaglandin synthesis at the site of injury and inflammation. This action leads to decreased swelling, stiffness, and discomfort, allowing improved joint movement and functional recovery.

Dosage and Administration

Dosage should be individualized based on patient condition and response:

• Adults: 25–50 mg taken two to three times daily

• Elderly patients: Use the lowest effective dose

A-Fenac Tablet should be taken after meals to reduce gastrointestinal irritation. The lowest effective dose should be used for the shortest duration necessary.

Drug Interactions

Diclofenac may interact with other NSAIDs, anticoagulants, antiplatelet agents, corticosteroids, antihypertensive drugs, and diuretics. Concomitant use may increase the risk of gastrointestinal bleeding or renal impairment. Medical supervision is advised when used with other medications.

Contraindications

A-Fenac Tablet 25 mg is contraindicated in patients with:

• Known hypersensitivity to diclofenac or other NSAIDs

• Active or history of peptic ulcer disease

• Severe hepatic, renal, or cardiac impairment

• History of NSAID-induced asthma or allergic reactions

Side Effects

A-Fenac Tablet is generally well tolerated at low doses. Possible side effects include:

• Gastrointestinal discomfort, nausea, or heartburn

• Headache or dizziness

• Skin rash (rare)

• Elevated liver enzymes with prolonged use

Most side effects are dose-related and reversible.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pregnancy and Lactation

A-Fenac Tablet should be used with caution during pregnancy and is contraindicated in the third trimester. Use during lactation should be based on a physician’s advice.

Storage Conditions

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.