Amdocal 10 mg is a long-acting calcium channel blocker used for the management of hypertension and coronary artery disease. It can be used alone or in combination with other antihypertensive or antianginal agents. Amdocal is effective in treating conditions such as chronic stable angina, vasospastic angina, and angiographically documented coronary artery disease in patients without heart failure or significantly reduced ejection fraction. Its dual action on the cardiovascular system helps reduce blood pressure, decrease myocardial oxygen demand, and improve blood flow to the heart.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Amdocal 10 mg is indicated for:

• Hypertension (high blood pressure)

• Coronary artery disease, including:

  • Chronic stable angina

  • Vasospastic (variant) angina

  • Angiographically documented coronary artery disease in patients without heart failure or ejection fraction <40%

Therapeutic Class

Calcium Channel Blockers

Pharmacology

Amdocal 10 mg works by inhibiting the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. This results in:

• Vasodilation of peripheral arteries, reducing peripheral vascular resistance and afterload

• Decreased cardiac contractility, lowering myocardial oxygen demand

• Coronary artery dilation, improving oxygen delivery to ischemic heart tissue

The antihypertensive effect is primarily due to direct relaxation of vascular smooth muscle, while the anti-anginal effect arises from a combination of reduced cardiac workload and improved myocardial perfusion.

Dosage and Administration

Adults:

• Starting dose: 5 mg once daily

• Maximum dose: 10 mg once daily

Pediatric (6–17 years):

• Starting dose: 2.5 mg once daily, up-titrated to 5 mg if blood pressure goal is not achieved after 4 weeks

• Children under 6 years: safety and efficacy not established

Special Populations:

• Elderly: normal adult dosage recommended; titrate carefully

• Hepatic impairment: start at 2.5 mg once daily and titrate slowly

• Renal impairment: no dose adjustment needed

Drug Interactions

Amdocal 10 mg can be safely co-administered with:

• Thiazide diuretics, alpha blockers, beta blockers

• ACE inhibitors, long-acting nitrates, sublingual nitroglycerin

• NSAIDs, antibiotics, oral hypoglycemic agents

Note: Grapefruit or grapefruit juice may increase bioavailability, enhancing blood pressure-lowering effects.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Known hypersensitivity to Amdocal 10 mg or any component of the formulation

Side Effects

Common side effects include:

• Headache

• Edema (dose-related)

• Fatigue, nausea, abdominal pain, somnolence

Rare but serious effects may occur in sensitive patients or with overdose.

Precautions and Warnings

• Symptomatic hypotension is possible, particularly in severe aortic stenosis

• Worsening angina or acute myocardial infarction may develop after initiating or increasing dosage in severe coronary artery disease

• Titrate slowly in patients with hepatic impairment

Overdose Management

Symptoms: Excessive vasodilation, reflex tachycardia, hypotension, shock
Management: Active cardiovascular support, IV fluids, elevation of extremities, intravenous calcium gluconate, gastric lavage if necessary, and monitoring of cardiac and respiratory function

Pregnancy and Lactation

• Pregnancy: Category C; use only if benefit outweighs risk

• Lactation: Excretion in breast milk unknown; consider discontinuing nursing

Storage Conditions

Store in a dry place, away from light and heat. Keep out of reach of children.