Amloten Tablet 5 mg + 25 mg is a fixed-dose combination of Amlodipine Besilate and Atenolol, designed for the effective management of hypertension and related cardiovascular conditions. By combining a calcium channel blocker with a cardioselective beta-blocker, Amloten provides dual action on blood pressure control, helping patients achieve better and more stable cardiovascular outcomes.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Amlodipine Besilate USP: 5 mg

• Atenolol USP: 25 mg

• Dosage Form: Oral tablet

Therapeutic Class

• Calcium Channel Blocker + Beta-1 Selective Adrenergic Blocker

• Antihypertensive and Antianginal combination

Indications

Amloten Tablet 5 mg + 25 mg is indicated for the treatment of:

• Essential Hypertension, especially when monotherapy is inadequate

• Chronic Stable Angina Pectoris

• Patients requiring combination therapy for effective blood pressure and heart rate control

• Reduction of cardiovascular risks such as stroke, myocardial infarction, and other complications associated with hypertension

Pharmacology

Amloten combines the complementary mechanisms of two well-established cardiovascular agents. Amlodipine Besilate inhibits the influx of calcium ions into vascular smooth muscle cells, leading to relaxation and dilation of peripheral blood vessels. This reduces systemic vascular resistance and lowers blood pressure without significantly affecting heart rate.

Atenolol is a cardioselective beta-1 adrenergic receptor blocker that decreases heart rate, myocardial contractility, and cardiac output. It also reduces renin release from the kidneys, contributing to further blood pressure reduction.

Together, these agents provide additive antihypertensive and antianginal effects, improving myocardial oxygen balance, reducing cardiac workload, and offering sustained 24-hour blood pressure control with once-daily dosing.

Dosage and Administration

• The usual dose is one tablet once daily, or as prescribed by a physician.

• The tablet should be swallowed whole with water, with or without food.

• Dose adjustments may be necessary based on individual patient response, age, and coexisting medical conditions.

• Abrupt discontinuation, especially of the beta-blocker component, should be avoided.

Side Effects

Amloten Tablet is generally well tolerated. Some patients may experience:

• Dizziness or fatigue

• Headache

• Peripheral edema

• Bradycardia or slow heart rate

• Cold extremities

• Gastrointestinal discomfort

Most adverse effects are mild and transient. Persistent or severe reactions require medical attention.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use with caution in patients with asthma, chronic obstructive pulmonary disease, diabetes, or heart conduction disorders.

• Not recommended during pregnancy and breastfeeding unless clearly advised by a physician.

• Regular monitoring of blood pressure and heart rate is advised.

• Patients should not stop the medication suddenly without medical guidance.

Drug Interactions

Amloten may interact with other antihypertensive drugs, antiarrhythmics, or agents affecting heart rate and blood pressure. Careful monitoring is required when used alongside calcium channel blockers, digoxin, or insulin.

Storage Conditions

• Store in a cool, dry place below 30°C

• Protect from light and moisture

• Keep out of reach of children.