Barri Tablet 2 mg contains Baricitinib, an oral Janus kinase (JAK) inhibitor used in the management of autoimmune and inflammatory disorders. It is mainly prescribed for patients with moderate to severe rheumatoid arthritis who have shown an inadequate response or intolerance to conventional disease-modifying antirheumatic drugs (DMARDs). The 2 mg strength is particularly suitable for patients who require a lower maintenance dose or dose adjustment due to age, renal impairment, or tolerability considerations.

By selectively targeting key inflammatory signaling pathways, Barri Tablet 2 mg helps control chronic inflammation, reduce joint pain and swelling, and improve overall physical function.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Baricitinib 2 mg

Therapeutic Class

Janus kinase (JAK) inhibitor
Disease-modifying antirheumatic drug (DMARD)

Indications

Barri Tablet 2 mg is indicated for:

• Moderate to severe rheumatoid arthritis in adults

• Patients with inadequate response to one or more conventional DMARDs

• Use as monotherapy or in combination with methotrexate or other non-biologic DMARDs

• Patients requiring dose reduction due to renal impairment or safety considerations

Pharmacology

Baricitinib is a selective inhibitor of Janus kinase 1 (JAK1) and Janus kinase 2 (JAK2), enzymes involved in the signaling pathways of multiple pro-inflammatory cytokines. These cytokines play a central role in the development and progression of autoimmune diseases such as rheumatoid arthritis.

By blocking JAK1 and JAK2 activity, Baricitinib reduces cytokine-mediated immune responses, leading to decreased inflammation, suppression of immune overactivity, and relief from clinical symptoms. Its targeted mechanism allows effective disease control while maintaining a balanced immune response.

Dosage and Administration

Barri Tablet 2 mg is taken orally.

• Recommended dose: 2 mg once daily or as directed by a physician

• May be taken with or without food

• Dose adjustment is recommended in elderly patients and in those with moderate renal impairment

Patients should adhere strictly to prescribed dosing and avoid self-adjustment of the dose.

Contraindications

Barri Tablet 2 mg is contraindicated in patients with:

• Known hypersensitivity to Baricitinib or any excipient

• Active serious infections, including tuberculosis

Side Effects

Possible side effects include:

• Upper respiratory tract infections

• Nausea

• Headache

• Elevated liver enzymes

• Changes in lipid profile

Less commonly, serious infections, thromboembolic events, and hematological abnormalities may occur, requiring close medical supervision.

Precautions and Warnings

• Screen patients for tuberculosis and viral hepatitis before initiating therapy

• Use with caution in patients with a history of recurrent infections

• Regular monitoring of complete blood count, liver function, and lipid levels is advised

• Caution is recommended in elderly patients and those with cardiovascular risk factors

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pregnancy and Lactation

Barri Tablet 2 mg should be used during pregnancy only if clearly necessary and when potential benefits outweigh risks. Breastfeeding is not recommended during treatment and for a period after discontinuation, as advised by a healthcare professional.

Storage Conditions

Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of the reach of children.

Mode of Action

Baricitinib inhibits JAK1 and JAK2 enzymes, disrupting inflammatory cytokine signaling pathways responsible for immune-mediated inflammation and tissue damage. This action helps reduce disease activity and improve patient outcomes.