Bexitrol F Inhaler (25 mcg + 50 mcg)/puff is a fixed-dose combination inhaler containing Salmeterol and Fluticasone Propionate, developed for the long-term maintenance treatment of bronchial asthma and chronic obstructive pulmonary disease (COPD). This lower-dose formulation is especially suitable for patients with mild persistent asthma or those who require a minimal effective dose of inhaled corticosteroid along with sustained bronchodilation.

The inhaler delivers medication directly to the lungs, ensuring rapid local action, improved symptom control, and reduced systemic side effects compared to oral therapies. Bexitrol F Inhaler is intended for regular, daily use and should not be used for the relief of sudden asthma attacks.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Long-acting beta-2 agonist (LABA) + Inhaled corticosteroid (ICS)

Indications

Bexitrol F Inhaler (25 mcg + 50 mcg)/puff is indicated for:

• Maintenance treatment of bronchial asthma in patients not adequately controlled on low-dose inhaled corticosteroids alone

• Long-term management of mild asthma requiring combination therapy

• Symptom prevention such as wheezing, chest tightness, breathlessness, and cough

This strength is often prescribed as an initial combination therapy or for patients stepping down from higher-dose inhaled corticosteroids once good symptom control is achieved.

Pharmacological Properties

Salmeterol is a selective long-acting beta-2 adrenergic receptor agonist. It works by relaxing the smooth muscles of the airways, resulting in prolonged bronchodilation for up to 12 hours. This helps prevent bronchospasm, improves airflow, and reduces nighttime and exercise-induced asthma symptoms.

Fluticasone Propionate is a potent inhaled corticosteroid with strong anti-inflammatory activity. It reduces airway inflammation by inhibiting inflammatory mediators, decreasing mucosal edema, and suppressing immune cell activation within the respiratory tract. Regular use lowers airway hyper-responsiveness and helps prevent asthma exacerbations.

Together, these two agents provide complementary and synergistic benefits—Salmeterol maintains open airways, while Fluticasone addresses the underlying inflammation that drives asthma and COPD.

Dosage and Administration

• For inhalation use only

• The usual dose is one puff twice daily, or as directed by a physician

• The inhaler should be used consistently at the same times each day

• Patients should rinse the mouth thoroughly with water after each use and spit it out to minimize the risk of oral candidiasis

Correct inhaler technique is essential to ensure optimal drug delivery and therapeutic effectiveness.

Contraindications

Bexitrol F Inhaler is contraindicated in:

• Patients with hypersensitivity to Salmeterol, Fluticasone Propionate, or any excipient

• Acute asthma attacks or status asthmaticus requiring fast-acting rescue medication

Possible Side Effects

Common or mild side effects may include:

• Throat irritation or hoarseness

• Headache

• Cough

• Oral fungal infections

• Palpitations or tremor (rare)

Most side effects are mild and can be minimized with proper inhaler use and mouth rinsing.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Not intended for immediate relief of acute bronchospasm

• Use cautiously in patients with cardiovascular disease, diabetes mellitus, or hyperthyroidism

• Do not stop treatment abruptly without medical advice

• Regular follow-up is recommended for long-term therapy

Use in Pregnancy and Lactation

Bexitrol F Inhaler should be used during pregnancy and breastfeeding only if clearly needed and under medical supervision.

Storage Conditions

Store below 30°C in a dry place, away from direct heat and sunlight. Keep out of reach of children.