Covikil Tablet 200 mg contains Hydroxychloroquine Sulphate, a well-established medication primarily used for autoimmune and inflammatory conditions. It belongs to the class of antimalarial and disease-modifying antirheumatic drugs (DMARDs) and has been extensively used for decades to manage conditions such as rheumatoid arthritis, systemic lupus erythematosus (SLE), and certain malaria infections.

Hydroxychloroquine works by modulating the immune system, reducing inflammation, and interfering with the communication pathways of immune cells. This action helps alleviate joint pain, swelling, and stiffness in autoimmune disorders. Additionally, Covikil exhibits antimalarial activity by preventing the growth and replication of Plasmodium species within red blood cells.

Covikil Tablet 200 mg is suitable for adults with chronic autoimmune disorders or as prescribed for malaria prevention or treatment. Its dual role as an immunomodulator and antimalarial makes it a versatile and essential therapy in specific medical conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Antimalarial

• Disease-Modifying Antirheumatic Drug (DMARD)

• Immunomodulatory Agent

Indications

Covikil Tablet 200 mg is indicated for:

• Rheumatoid arthritis – to reduce inflammation, joint pain, and stiffness

• Systemic lupus erythematosus (SLE) – to control flares and systemic manifestations

• Malaria – prophylaxis or treatment of sensitive strains of Plasmodium species

• Other autoimmune conditions as determined by a physician

Pharmacology

Hydroxychloroquine Sulphate exerts its effects through multiple mechanisms:

• Immunomodulatory action: Reduces activation of T-cells and antigen-presenting cells, suppressing inappropriate immune responses

• Anti-inflammatory effect: Inhibits cytokine production, reducing inflammation in joints and tissues

• Antimalarial action: Interferes with parasite growth inside red blood cells by increasing the pH within the parasite’s lysosome, preventing replication

The drug is slowly absorbed after oral administration, distributed widely in body tissues, and metabolized in the liver. Its long half-life allows for once or twice daily dosing depending on the condition being treated.

Dosage and Administration

• Rheumatoid arthritis / SLE: Usually 200–400 mg daily, taken with meals to reduce gastrointestinal discomfort

• Malaria prophylaxis: Typically 200 mg once weekly (as per local guidelines)

• Malaria treatment: 800 mg loading dose followed by 400 mg at 6, 24, and 48 hours

• Swallow tablets whole with water

• Dosing may be adjusted according to age, weight, renal, and hepatic function

Contraindications

• Hypersensitivity to hydroxychloroquine, chloroquine, or related compounds

• Pre-existing retinal or visual field abnormalities

• Severe liver or kidney impairment

• History of cardiac conduction disorders

Side Effects

Common adverse effects may include:

• Nausea, vomiting, or abdominal discomfort

• Headache or dizziness

• Skin rashes or itching

Serious but rare effects include:

• Retinopathy (monitor vision periodically)

• Cardiomyopathy or conduction abnormalities

• Myopathy or neuropathy

Regular ophthalmologic examinations are recommended for long-term use.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Pregnancy and Lactation

• Hydroxychloroquine may be used during pregnancy and lactation only if clearly indicated and under physician supervision

• Can help manage autoimmune conditions safely in many cases

Precautions and Warnings

• Regular monitoring of eye health, liver, and kidney function is advised during long-term therapy

• Use cautiously in patients with cardiac, renal, or hepatic disorders

• Avoid abrupt discontinuation in autoimmune diseases, as it may trigger flares

Storage Conditions

• Store in a cool, dry place below 30°C

• Protect from light and moisture

• Keep out of reach of children.