Denbac Capsule 25 mg contains Dantrolene Sodium, a peripherally acting skeletal muscle relaxant used for the management of spasticity associated with neurological disorders and for the treatment and prevention of malignant hyperthermia. It works directly on skeletal muscle fibers to reduce excessive contraction and rigidity without affecting the central nervous system significantly.

This lower-strength formulation is useful for dose titration and individualized long-term spasticity management.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each capsule contains:

• Dantrolene Sodium 25 mg

Mechanism of Action

Dantrolene Sodium acts directly on skeletal muscle by inhibiting calcium release from the sarcoplasmic reticulum through ryanodine receptor channels (RyR1). This reduces intracellular calcium availability, leading to decreased muscle contraction and relaxation of spastic muscles. In malignant hyperthermia, it helps reverse uncontrolled calcium release that causes life-threatening muscle rigidity and hypermetabolic state.

Indications

Denbac Capsule 25 mg is indicated for:

• Chronic spasticity due to neurological conditions such as cerebral palsy, multiple sclerosis, and spinal cord injury
• Post-stroke muscle spasticity
• Malignant hyperthermia (treatment and prophylaxis under anesthesia)
• Severe muscle rigidity and spasm disorders

Dosage and Administration

• To be taken orally as directed by a physician
• Dose is gradually titrated based on clinical response and tolerance
• Should be swallowed whole with water
• In malignant hyperthermia, use is strictly hospital-based and emergency-controlled
• Long-term therapy requires regular liver function monitoring

Contraindications

Denbac Capsule should not be used in:

• Known hypersensitivity to Dantrolene Sodium
• Active liver disease or significant hepatic impairment
• Patients where muscle weakness may worsen functional status without supervision

Side Effects

Possible side effects include:

• Muscle weakness
• Drowsiness or dizziness
• Fatigue
• Diarrhea
• Nausea or vomiting
• Elevated liver enzymes
• Rare hepatotoxicity with prolonged use
• Skin rash (rare)

Precautions

• Regular monitoring of liver function tests is essential
• Use cautiously in elderly or debilitated patients
• May impair muscle strength affecting mobility and daily activities
• Avoid alcohol due to increased sedation and liver risk
• Patients should be monitored for signs of liver toxicity during long-term use

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Denbac Capsule may interact with:

• CNS depressants (enhanced sedation)
• Other muscle relaxants (additive muscle weakness)
• Hepatotoxic medications (increased risk of liver damage)
• Calcium channel blockers (may potentiate muscle-related effects)

Storage Conditions

• Store below 30°C in a cool, dry place
• Protect from light and moisture
• Keep out of reach of children.