Kilbac 1.5 gm Vial contains Cefuroxime, a second-generation cephalosporin antibiotic with broad-spectrum bactericidal activity. It is indicated for the treatment of infections caused by susceptible bacteria, including strains producing β-lactamase. Cefuroxime is effective against a wide range of Gram-positive and Gram-negative pathogens and is stable against bacterial β-lactamase, making it a reliable choice for infections resistant to ampicillin or amoxicillin.

Kilbac is available as an injectable solution for intravenous (IV) or intramuscular (IM) administration, making it suitable for moderate to severe infections requiring parenteral therapy. Its pharmacological profile ensures rapid bacterial killing while maintaining safety in most patient populations.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Kilbac 1.5 gm is indicated for the treatment of infections caused by sensitive bacteria, including:

• Upper respiratory tract infections:

  • Pharyngitis and tonsillitis caused by Streptococcus pyogenes

  • Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, or Streptococcus pyogenes

  • Acute bacterial maxillary sinusitis

• Lower respiratory tract infections:

  • Pneumonia and acute exacerbations of chronic bronchitis caused by S. pneumoniae, H. influenzae, Klebsiella spp., S. aureus, S. pyogenes, or E. coli

• Skin and soft tissue infections:

  • Caused by S. aureus (including β-lactamase producing strains) or S. pyogenes

• Urinary tract infections:

  • Caused by E. coli or K. pneumoniae

• Bone and joint infections:

  • Caused by S. aureus

• Sexually transmitted infections:

  • Gonorrhoea caused by penicillinase-producing and non-penicillinase-producing Neisseria gonorrhoeae

• Early Lyme disease:

  • Erythema migrans caused by Borrelia burgdorferi

• Surgical prophylaxis:

  • Prevents infections in high-risk surgical procedures

Therapeutic Class

• Second-generation Cephalosporins

Pharmacology and Mode of Action

Cefuroxime exhibits broad-spectrum bactericidal activity by inhibiting bacterial cell wall synthesis. It is stable against β-lactamase enzymes, which makes it effective against ampicillin- and amoxicillin-resistant strains. Its activity covers both Gram-positive and Gram-negative organisms commonly responsible for respiratory, urinary, skin, and soft tissue infections.

Dosage and Administration

Parenteral Administration (IV/IM):

• Adults:

  • Standard dose: 750 mg IV/IM three times daily

  • Severe infections: Up to 1.5 gm IV three times daily

  • Pneumonia: 1.5 gm IV twice daily for 2–3 days, followed by oral 500 mg twice daily

  • Gonorrhoea: 1.5 gm single dose (2 × 750 mg IM injections at different sites)

• Children (>3 months): 30–100 mg/kg/day in 3–4 divided doses

• Neonates: 30–100 mg/kg/day in 2–3 divided doses

• Surgical prophylaxis: 1.5 gm IV at induction; additional 750 mg doses every 8 hours for high-risk procedures

Reconstitution Instructions:

• 750 mg IM: Add 3 ml water for injection

• 750 mg IV: Add 8 ml water for injection

• 1.5 gm IV: Add 16 ml water for injection

• Inject slowly over 3–5 minutes

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• No significant hazardous interactions reported

Contraindications

• Known hypersensitivity to cephalosporins

Side Effects

• Generally mild and transient: rashes, gastrointestinal disturbances

• Prolonged use may lead to overgrowth of non-susceptible organisms (e.g., Candida)

Precautions and Warnings

• Use with caution in patients on potent diuretics or with history of colitis

• Cephalosporins may rarely cross-react in penicillin-sensitive patients

• Adjust dose in severe infections or compromised renal function

Pregnancy and Lactation

• Pregnancy Category B (FDA): Use only if clearly needed

• Excreted in breast milk; caution advised for nursing mothers

Storage Conditions

Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.