Letrozol Tablet 2.5 mg contains Letrozole, an aromatase inhibitor widely used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. Letrozole works by blocking the aromatase enzyme, which converts androgens into estrogen. By reducing estrogen levels in the body, Letrozole helps slow or stop the growth of estrogen-dependent breast cancer cells.

This tablet is primarily prescribed for adjuvant therapy, advanced or metastatic breast cancer, and as part of fertility treatments in certain cases. Letrozol Tablet 2.5 mg is an oral therapy offering convenience, effective hormone suppression, and improved outcomes in estrogen-sensitive breast cancer.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Mechanism of Action

Letrozole functions as a non-steroidal aromatase inhibitor. Its mechanism includes:

• Inhibition of aromatase enzyme: Prevents the conversion of androgens into estrogen in peripheral tissues.

• Reduction of estrogen levels: Lowers circulating estrogen concentrations, limiting stimulation of estrogen receptor-positive tumor cells.

• Suppression of tumor growth: Decreased estrogen availability slows or stops the proliferation of hormone-dependent breast cancer cells.

Unlike selective estrogen receptor modulators (SERMs) such as tamoxifen, Letrozole does not block estrogen receptors but prevents estrogen production, offering a targeted approach to hormone therapy.

Indications

Letrozol Tablet 2.5 mg is indicated for:

• Postmenopausal women with hormone receptor-positive breast cancer: As adjuvant therapy after surgery or radiotherapy.

• Advanced or metastatic breast cancer: To slow progression in estrogen-sensitive tumors.

• Fertility treatment: Off-label use to induce ovulation in women with ovulatory dysfunction, under medical supervision.

This therapy is specifically suited for patients who benefit from estrogen suppression due to tumor dependence on hormonal stimulation.

Dosage and Administration

• The standard adult dose is 2.5 mg once daily, taken orally, with or without food.

• Tablets should be swallowed whole with a glass of water.

• Therapy duration depends on the indication:

  • Adjuvant therapy: Typically 5 years, or as determined by the oncologist.

  • Advanced breast cancer: Until disease progression or unacceptable toxicity.

• Regular monitoring of liver function, bone density, and lipid profile is recommended during treatment.

Precautions

• Inform your doctor if you have liver disease, osteoporosis, cardiovascular disease, or history of fractures.

• Use with caution in women of childbearing age; effective contraception is advised during treatment.

• Not suitable for premenopausal women unless combined with ovarian suppression therapy.

• Patients should report symptoms such as severe bone pain, hot flashes, or cardiovascular changes.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects include:

• Hot flashes and sweating

• Fatigue or weakness

• Joint and muscle pain (arthralgia and myalgia)

• Nausea or vomiting

• Headache

Less common but serious side effects may include bone loss, fractures, liver toxicity, and cardiovascular events. Regular monitoring and supplementation with calcium and vitamin D are recommended to reduce bone-related risks.

Storage

Store below 30°C in a dry place, away from sunlight and moisture. Keep out of reach of children.

Letrozol Tablet 2.5 mg provides effective estrogen suppression therapy, offering targeted treatment for hormone receptor-positive breast cancer, improved patient outcomes, and convenient oral administration under medical supervision.