Mircera Injection 100 µg/0.3 ml contains Methoxy Polyethylene Glycol-Epoetin Beta, a long-acting erythropoiesis-stimulating agent (ESA) indicated for the treatment of anemia associated with chronic kidney disease (CKD). It supports the production of red blood cells by stimulating erythropoietin receptors in the bone marrow, helping to increase and maintain healthy hemoglobin levels.

In patients with CKD, the kidneys produce insufficient amounts of natural erythropoietin, leading to anemia. Mircera’s advanced continuous erythropoietin receptor activator (CERA) technology llows sustained stimulation of red blood cell production, enabling extended dosing intervals compared to conventional ESAs.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Extended duration of action
  Provides long-lasting erythropoietic stimulation.

• Convenient dosing schedule
  Administered once every two weeks or once monthly, depending on patient needs.

• Effective hemoglobin maintenance
  Helps achieve and maintain target hemoglobin levels.

• Suitable for dialysis and non-dialysis patients
  Can be used in adult CKD patients receiving or not receiving dialysis.

Indications

Mircera Injection 100 µg/0.3 ml is indicated for:

• Treatment of anemia associated with chronic kidney disease in adult patients.

• Maintenance therapy to stabilize hemoglobin levels in CKD patients.

Treatment must be initiated and monitored by a healthcare professional experienced in anemia management.

Dosage and Administration

• Administered via subcutaneous (SC) or intravenous (IV) injection.

• Dosage is individualized based on hemoglobin level, body weight, and response to therapy.

• Hemoglobin levels should be monitored regularly to guide dose adjustments.

• Iron deficiency should be corrected before and during therapy to ensure optimal response.

Do not shake the prefilled syringe. Use under strict medical supervision.

Mechanism of Action

Methoxy Polyethylene Glycol-Epoetin Beta binds to erythropoietin receptors on erythroid progenitor cells in the bone marrow. Its continuous receptor activation results in sustained stimulation of red blood cell production, promoting gradual and stable increases in hemoglobin.

Safety Information

Contraindications:

• Uncontrolled hypertension.

• Hypersensitivity to methoxy polyethylene glycol-epoetin beta or any component of the formulation.

Warnings and precautions:

• Regular monitoring of blood pressure is essential.

• Avoid targeting hemoglobin levels higher than recommended to reduce cardiovascular risks.

• Risk of thromboembolic events may increase with rapid or excessive hemoglobin rise.

• Ongoing laboratory monitoring is necessary during treatment.

Common side effects may include hypertension, headache, injection site reactions, and vascular access thrombosis in dialysis patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

Store in a refrigerator at 2°C to 8°C. Do not freeze. Keep in the original packaging to protect from light. Keep out of reach of children.