Tocit XR Tablet 11 mg contains Tofacitinib 11 mg in an extended-release (XR) formulation, designed for the treatment of autoimmune conditions such as ulcerative colitis in adults. Tofacitinib is a Janus kinase (JAK) inhibitor that helps regulate the overactive immune system, reducing inflammation, preventing tissue damage, and controlling disease progression.

The extended-release formulation of Tocit XR allows for once-daily dosing, providing convenient and consistent therapeutic effects throughout the day. This tablet is particularly useful for patients with moderate to severe ulcerative colitis who require long-term management to maintain remission and prevent flare-ups.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Tofacitinib 11 mg (Extended-Release)

Mechanism of Action

Tocit XR works by selectively inhibiting Janus kinase (JAK) enzymes, which play a central role in the signaling of pro-inflammatory cytokines:

1. Immune system modulation – Reduces abnormal immune activity that causes chronic inflammation in the intestinal tract.

2. Anti-inflammatory effect – Decreases the production of inflammatory mediators, alleviating pain, diarrhea, and rectal bleeding associated with ulcerative colitis.

3. Tissue protection – Slows progression of mucosal damage in the colon, supporting long-term gut health and preventing complications.

The extended-release design maintains steady drug levels in the bloodstream, minimizing fluctuations and enhancing adherence to therapy.

Indications

Tocit XR Tablet 11 mg is indicated for:

• Induction and maintenance of remission in moderate to severe ulcerative colitis in adult patients

• Patients who have had an inadequate response, lost response, or were intolerant to conventional therapy, including corticosteroids or immunomodulators

• Part of a comprehensive treatment plan for autoimmune intestinal inflammation under the supervision of a gastroenterologist

Dosage and Administration

• Recommended dose: 11 mg orally, once daily

• Swallow the tablet whole; do not crush, chew, or split the XR tablet

• Can be taken with or without food

• Regular monitoring is essential, including blood counts, liver function, and kidney function

• Avoid sudden discontinuation to prevent flare-ups of ulcerative colitis

• Dose adjustments may be required in patients with moderate to severe liver or kidney impairment

Benefits

• Provides effective induction and maintenance of remission in ulcerative colitis

• Reduces symptoms such as diarrhea, abdominal pain, rectal bleeding, and urgency

• Convenient once-daily dosing improves adherence and patient convenience

• Helps prevent long-term intestinal damage and complications

• Offers a safe and effective alternative for patients intolerant or unresponsive to conventional therapies

Precautions

• Avoid use in patients with active infections, severe liver disease, or history of blood disorders

• Monitor closely for infections, including tuberculosis, viral, bacterial, and fungal infections

• Avoid live vaccines during treatment

• Patients with history of cardiovascular disease, malignancy, or blood clotting disorders should be monitored carefully

• Not recommended during pregnancy or breastfeeding unless specifically advised by a healthcare provider

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Upper respiratory tract infections

• Headache

• Nausea or diarrhea

• Elevated cholesterol or liver enzyme levels

• Mild fatigue

Serious side effects requiring immediate attention:

• Severe infections or fever

• Blood clots, such as deep vein thrombosis or pulmonary embolism

• Unexplained bruising or bleeding

• Shortness of breath or chest pain

Storage

• Store below 30°C in a cool, dry place

• Protect from moisture and direct sunlight

• Keep the bottle tightly closed

• Keep out of reach of children

Tocit XR Tablet 11 mg is an effective extended-release therapy for adults with moderate to severe ulcerative colitis, providing consistent symptom control and supporting long-term gut health under proper medical supervision.