Unipim Injection 1 gm/vial contains Cefepime Hydrochloride 1 gram, a potent fourth-generation cephalosporin antibiotic with broad-spectrum activity against Gram-negative and Gram-positive bacteria. It is specifically designed for the treatment of serious, complicated, and hospital-acquired infections, including infections caused by multi-drug resistant organisms.

Cefepime, the active ingredient, is highly effective against pathogens such as Escherichia coli, Klebsiella species, Pseudomonas aeruginosa, and Staphylococcus aureus. Unipim Injection 1 gm is widely used for severe infections including pneumonia, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, septicemia, and bone or joint infections, providing rapid bactericidal activity and reliable therapeutic outcomes.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Cefepime Hydrochloride 1 gm per vial

Mechanism of Action

Cefepime, a fourth-generation cephalosporin, works by:

1. Inhibiting bacterial cell wall synthesis – Binds to penicillin-binding proteins (PBPs), preventing cross-linking of peptidoglycan layers essential for bacterial cell wall integrity.

2. Bactericidal effect – Disruption of the cell wall causes bacterial lysis and death.

3. Broad-spectrum coverage – Effective against Gram-negative bacteria including Pseudomonas aeruginosa and many Gram-positive bacteria.

4. Resistance stability – Maintains activity against bacteria resistant to earlier-generation cephalosporins due to β-lactamase stability.

This mechanism ensures rapid elimination of pathogens, making it suitable for severe and complicated infections.

Indications

Unipim Injection 1 gm/vial is indicated for:

• Severe respiratory tract infections – including community-acquired and hospital-acquired pneumonia

• Urinary tract infections – complicated infections, pyelonephritis, and urosepsis

• Skin and soft tissue infections – cellulitis, abscesses, post-surgical wound infections

• Intra-abdominal infections – peritonitis, cholecystitis, and secondary bacterial infections

• Septicemia and bloodstream infections – caused by susceptible pathogens

• Bone and joint infections – osteomyelitis and septic arthritis

It is suitable for adults and pediatric patients under proper medical supervision, with dose adjustments for renal impairment.

Dosage and Administration

• Administer intravenously (IV) or intramuscularly (IM) after reconstitution using aseptic technique.

• Adults: Typically 1 g every 12 hours, adjustable based on infection severity and renal function.

• Pediatric patients: Dosage calculated according to body weight and clinical condition.

• Duration of therapy is determined by infection type, severity, and clinical response.

• Renal function should be monitored, and dose adjustment is necessary in cases of impairment.

Benefits

• Rapid bactericidal activity against a wide range of bacteria

• Effective against multi-drug resistant Gram-negative and Gram-positive organisms

• Suitable for hospital-acquired and complicated infections

• Can be administered IV or IM for versatile clinical use

• Supports both monotherapy and combination therapy for critical infections

Precautions

• Use cautiously in patients with penicillin or cephalosporin allergy.

• Monitor renal function during prolonged therapy.

• Avoid unnecessary prolonged use to reduce the risk of antibiotic resistance.

• Watch for signs of superinfection, including Clostridium difficile-associated diarrhea.

• Pregnancy and lactation: Use only if clearly indicated by a physician.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects:

• Pain, redness, or swelling at injection site

• Gastrointestinal disturbances: nausea, vomiting, diarrhea

• Mild headache or dizziness

Serious but rare side effects:

• Severe allergic reactions, including anaphylaxis

• Clostridium difficile-associated colitis

• Blood disorders: neutropenia, thrombocytopenia, or eosinophilia

Storage

• Store below 25°C in a cool, dry place

• Protect from light and moisture

• Keep vial tightly closed until use

• Keep out of reach of children

Unipim Injection 1 gm/vial is a potent fourth-generation cephalosporin antibiotic offering broad-spectrum coverage and rapid bactericidal action for severe and complicated bacterial infections under medical supervision.