Unipim Injection 500 mg/vial contains Cefepime Hydrochloride 500 mg, a fourth-generation cephalosporin antibiotic with broad-spectrum activity against both Gram-positive and Gram-negative bacteria. It is specifically designed for the treatment of serious, complicated, and hospital-acquired infections, including those caused by multi-drug resistant organisms.

Cefepime, the active ingredient in Unipim, is highly effective against common pathogens such as Escherichia coli, Klebsiella species, Pseudomonas aeruginosa, and Staphylococcus aureus. Unipim Injection is widely used for severe infections like pneumonia, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, and septicemia, offering rapid bactericidal action and reliable therapeutic outcomes.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Cefepime Hydrochloride 500 mg per vial

Mechanism of Action

Cefepime, a fourth-generation cephalosporin, exerts its antibacterial effect by:

1. Inhibiting bacterial cell wall synthesis – Binds to penicillin-binding proteins (PBPs), disrupting the cross-linking of peptidoglycan layers essential for bacterial cell wall integrity.

2. Bactericidal activity – Weakening the cell wall leads to osmotic instability, resulting in bacterial lysis and death.

3. Broad-spectrum coverage – Active against both Gram-positive and Gram-negative bacteria, including β-lactamase-producing strains.

4. Resistance stability – Maintains activity against organisms resistant to earlier-generation cephalosporins, making it suitable for complicated and hospital-acquired infections.

Through these mechanisms, Unipim Injection rapidly controls infection progression and reduces complications in severe bacterial infections.

Indications

Unipim Injection 500 mg/vial is indicated for:

• Severe respiratory tract infections – including community-acquired and hospital-acquired pneumonia

• Urinary tract infections – complicated infections and pyelonephritis

• Skin and soft tissue infections – cellulitis, abscesses, and post-surgical wound infections

• Intra-abdominal infections – peritonitis, cholecystitis, and other secondary infections

• Septicemia and bloodstream infections – caused by susceptible pathogens

• Bone and joint infections – osteomyelitis and septic arthritis

It is suitable for adult and pediatric patients, with dosage adjustments for renal impairment.

Dosage and Administration

• Administration: Intravenous (IV) or intramuscular (IM) injection after reconstitution under aseptic conditions.

• Adults: Typically 500 mg to 2 g every 12 hours, depending on infection severity.

• Pediatric patients: Dosage based on body weight and clinical condition.

• Dose adjustments are required in patients with impaired renal function to prevent toxicity.

• Duration of therapy depends on the type and severity of infection and clinical response.

Benefits

• Rapid and effective bactericidal activity against a wide range of bacteria

• Effective against multi-drug resistant Gram-negative and Gram-positive organisms

• Suitable for severe, complicated, and hospital-acquired infections

• Versatile administration via IV or IM routes

• Supports monotherapy or combination therapy in critical infections

Precautions

• Use cautiously in patients with known penicillin or cephalosporin allergy.

• Monitor renal function during prolonged therapy; adjust dosage if necessary.

• Avoid unnecessary prolonged use to reduce the risk of antibiotic resistance.

• Observe for signs of superinfection or Clostridium difficile-associated diarrhea.

• Pregnancy and lactation: Use only if clearly indicated by a physician.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects:

• Pain, redness, or swelling at injection site

• Gastrointestinal disturbances: nausea, vomiting, diarrhea

• Headache or mild dizziness

Serious but rare side effects:

• Severe allergic reactions: rash, itching, or anaphylaxis

• Clostridium difficile-associated colitis

• Blood disorders: neutropenia, thrombocytopenia, or eosinophilia

Storage

• Store below 25°C in a cool, dry place

• Protect from light and moisture

• Keep the vial tightly closed until use

• Keep out of reach of children

Unipim Injection 500 mg/vial is a potent fourth-generation cephalosporin antibiotic, providing broad-spectrum coverage and rapid bactericidal activity for serious and complicated bacterial infections under careful medical supervision.