Varizil Tablet 400 mg contains Metronidazole 400 mg, a widely used antibacterial and antiprotozoal agent. It is highly effective against anaerobic bacteria and certain protozoa, making it a key therapeutic option for gastrointestinal infections, gynecological infections, dental infections, and skin or soft tissue infections.

Metronidazole acts rapidly to inhibit the growth of bacteria and protozoa by disrupting their DNA synthesis. Varizil Tablet 400 mg is especially useful in infections caused by Bacteroides species, Clostridium species, Giardia lamblia, Trichomonas vaginalis, and Entamoeba histolytica, offering fast symptom relief and effective eradication of pathogenic microorganisms.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Metronidazole 400 mg per tablet

Mechanism of Action

Metronidazole, the active ingredient in Varizil Tablet 400 mg, works through:

1. Inhibition of nucleic acid synthesis – Metronidazole enters bacterial or protozoal cells and is reduced to an active metabolite that binds to DNA, causing strand breakage and inhibition of nucleic acid synthesis.

2. Bactericidal and protozoacidal effect – Leads to rapid cell death of anaerobic bacteria and protozoa.

3. Selective activity against anaerobic organisms – Targets pathogens in low-oxygen environments, such as the gastrointestinal tract, genitourinary tract, and abscesses.

4. Rapid onset of action – Provides fast relief from infection symptoms, reducing inflammation and discomfort.

This dual antibacterial and antiprotozoal activity makes Varizil 400 mg a versatile and effective treatment for a wide range of infections.

Indications

Varizil Tablet 400 mg is indicated for:

• Anaerobic bacterial infections – Such as intra-abdominal infections, abscesses, and skin infections

• Protozoal infections – Including giardiasis, trichomoniasis, and amoebiasis

• Gynecological infections – Bacterial vaginosis and pelvic inflammatory disease

• Dental infections – Periodontal and odontogenic infections caused by anaerobic bacteria

• Gastrointestinal infections – Helicobacter pylori eradication in combination therapy for peptic ulcers

It is suitable for adult patients and should be taken under the supervision of a healthcare professional.

Dosage and Administration

• Adults: 400 mg orally, 2–3 times daily, depending on infection type and severity.

• Take with or after meals to minimize gastrointestinal discomfort.

• Swallow the tablet whole with water.

• Complete the full course of therapy even if symptoms improve early, to prevent recurrence or resistance.

• Duration of treatment depends on the nature and severity of the infection, typically 5–10 days.

Benefits

• Rapid and effective treatment of anaerobic bacterial and protozoal infections

• Versatile use in gastrointestinal, gynecological, dental, and skin infections

• Helps reduce inflammation and infection-related discomfort

• Supports combination therapy for Helicobacter pylori eradication

• Well-tolerated and widely used in clinical practice

Precautions

• Avoid alcohol during treatment and for at least 48 hours after the last dose, as it may cause a disulfiram-like reaction (nausea, vomiting, flushing).

• Use cautiously in patients with liver disease, blood disorders, or hypersensitivity to metronidazole.

• Pregnancy and breastfeeding: Only use if clearly indicated and prescribed by a physician.

• May interact with anticoagulants and certain other medications; consult a physician or pharmacist before use.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects:

• Nausea, vomiting, or diarrhea

• Metallic taste in the mouth

• Mild headache or dizziness

Rare side effects:

• Allergic reactions such as rash or itching

• Neurological effects like peripheral neuropathy with prolonged use

• Severe gastrointestinal disturbances

Storage

• Store below 25°C in a cool, dry place

• Protect from light and moisture

• Keep out of reach of children

• Keep the blister pack intact until use

Varizil Tablet 400 mg is a highly effective antibacterial and antiprotozoal medication that treats a wide range of infections, including gastrointestinal, gynecological, dental, and skin infections, ensuring rapid symptom relief and microbial eradication.