Vaxitet Injection 40 IU/0.5 ml is an adsorbed tetanus vaccine used to prevent tetanus infection, a serious and potentially life-threatening disease caused by Clostridium tetani. This vaccine stimulates the immune system to produce protective antibodies against the tetanus toxin, offering active immunization and long-lasting protection. Vaxitet is suitable for both primary immunization and booster doses in adults and children, contributing to global tetanus control efforts.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Vaccines & Toxoids

• Active Immunizing Agent

Pharmacology

Vaxitet contains tetanus toxoid, an inactivated form of the tetanus neurotoxin. The toxoid is adsorbed onto an adjuvant to enhance the immune response. Upon administration, the vaccine triggers the immune system to produce antibodies that neutralize the tetanus toxin. These antibodies provide protective immunity, allowing the body to respond rapidly and effectively if exposed to Clostridium tetani.

The vaccine does not contain live bacteria and cannot cause tetanus. Protective antibody levels are generally achieved after the full primary vaccination series, and booster doses help maintain immunity over time.

Indications

Vaxitet Injection is indicated for:

• Active immunization against tetanus in adults and children

• Use as a primary series in individuals with no prior tetanus vaccination

• Booster doses for individuals who have previously completed the primary vaccination series

• Post-exposure prophylaxis in cases of potentially tetanus-prone wounds, particularly if the vaccination history is incomplete or uncertain

Dosage and Administration

• Adults and adolescents: 0.5 ml per dose intramuscularly

• Children: 0.5 ml per dose intramuscularly

• Primary immunization: Usually given as a series of 3 doses, with 4–8 weeks between each dose

• Booster dose: Recommended every 10 years to maintain immunity

• The injection should be administered deep into the deltoid muscle (or anterolateral thigh in infants)

• For post-exposure prophylaxis, additional doses may be recommended depending on the wound type and vaccination history

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Conditions

• Store at 2°C to 8°C

• Do not freeze

• Protect from light

• Keep out of reach of children

Contraindications

• Known hypersensitivity to any component of the vaccine, including the adjuvant

• Individuals who have experienced severe allergic reactions to a previous dose of tetanus vaccine

Precautions and Warnings

• Administer with caution in individuals with a history of severe allergic reactions

• Postpone vaccination in cases of moderate or severe acute illness until recovery

• Inform the healthcare provider about any chronic illness or immune system disorders

• Monitor for rare adverse events following immunization

Side Effects

Vaxitet Injection is generally well tolerated. Common side effects include:

• Mild pain, redness, or swelling at the injection site

• Low-grade fever

• Fatigue or mild malaise

• Rarely, headache or muscle aches

Severe allergic reactions are extremely rare but require immediate medical attention.

Pregnancy and Lactation

• Tetanus vaccination is safe during pregnancy and is recommended to protect both mother and newborn against neonatal tetanus

• Can be administered during breastfeeding

Mechanism of Action

Vaxitet Injection induces active immunity by stimulating the production of antitoxin antibodies against tetanus toxin. Upon future exposure to Clostridium tetani, these antibodies neutralize the toxin, preventing the development of tetanus symptoms such as muscle stiffness and spasms.