Verquv Tablet 10 mg contains Vericiguat, a soluble guanylate cyclase (sGC) stimulator specifically developed for the management of chronic heart failure with reduced ejection fraction (HFrEF). This medication is prescribed for patients who continue to experience symptoms despite optimal standard therapy, including ACE inhibitors, beta-blockers, and mineralocorticoid receptor antagonists.

Vericiguat enhances the nitric oxide–sGC–cGMP pathway, leading to vasodilation, improved cardiac function, and reduced cardiac stress, ultimately lowering the risk of hospitalization and cardiovascular death. Its once-daily oral dosing ensures convenience and adherence for long-term management.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Verquv Tablet 10 mg is indicated for:

• Chronic heart failure with reduced ejection fraction (HFrEF)
• Patients with persistent symptoms despite optimized heart failure therapy
• Reducing the risk of heart failure-related hospitalization and cardiovascular mortality

Mechanism of Action

Vericiguat works as a soluble guanylate cyclase stimulator:

• Stimulates sGC, enhancing the nitric oxide (NO) signaling pathway
• Increases levels of cyclic guanosine monophosphate (cGMP)
• Promotes vasodilation, reducing cardiac preload and afterload
• Improves left ventricular function and reduces adverse cardiac remodeling
• Complements other heart failure therapies to slow disease progression and improve outcomes

By targeting the NO–sGC–cGMP pathway, Vericiguat helps maintain cardiac efficiency and symptom control in chronic heart failure.

Dosage and Administration

• Recommended dose: 10 mg once daily, orally
• Can be taken with or without food
• Swallow the tablet whole with water
• Dose adjustments may be made based on blood pressure, renal function, and patient tolerance
• Regular monitoring by a healthcare provider is advised for optimal safety and efficacy

Benefits

• Reduces hospitalization and cardiovascular mortality in HFrEF patients
• Improves exercise tolerance and symptom control
• Convenient once-daily oral dosing enhances adherence
• Works alongside other heart failure medications, including ACE inhibitors, beta-blockers, and diuretics
• Supports long-term preservation of cardiac function

Side Effects

Common side effects may include:

• Dizziness or lightheadedness
• Hypotension (low blood pressure)
• Headache
• Fatigue

Rare but serious side effects:

• Severe hypotension or syncope
• Allergic reactions such as rash, swelling, or difficulty breathing

Immediate medical attention is necessary if serious or persistent symptoms occur.

Precautions and Warnings

• Use cautiously in patients with hypotension, severe renal or hepatic impairment
• Avoid concomitant use with nitrates or nitric oxide donors due to risk of severe hypotension
• Monitor blood pressure, renal function, and electrolytes regularly
• Pregnancy and breastfeeding: only use under medical supervision
• Do not abruptly discontinue therapy without consulting your physician

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Vericiguat may interact with:

• Nitrates or nitric oxide donors (risk of severe hypotension)
• PDE5 inhibitors (may enhance hypotensive effects)
• Medications affecting renal or hepatic clearance

Always inform your healthcare provider of all medications and supplements before starting therapy.

Storage

• Store below 30°C in a dry, cool place
• Protect from light and moisture
• Keep out of reach of children
• Do not use after the expiration date.