istarin Injection 4000 Anti-Xa IU/0.4 ml contains Enoxaparin Sodium, a low molecular weight heparin (LMWH) used for prevention and treatment of blood clots. It is an anticoagulant that works by inhibiting clotting factors in the blood, particularly Factor Xa, thereby reducing the risk of deep vein thrombosis (DVT), pulmonary embolism (PE), and other thromboembolic disorders.

This injection provides a safe and effective alternative to standard heparin therapy, offering predictable anticoagulant effects with a lower risk of bleeding complications. Its pre-filled dosage ensures accurate administration and convenience for patients requiring anticoagulation therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Vistarin Injection 4000 Anti-Xa IU/0.4 ml is indicated for:

• Prevention of venous thromboembolism (VTE) in patients undergoing surgery or at high risk of clot formation
• Treatment of deep vein thrombosis (DVT) with or without pulmonary embolism (PE)
• Prevention of clot formation in patients with acute coronary syndrome (ACS)
• Adjunct therapy in myocardial infarction to prevent further thrombus formation

Mechanism of Action

Enoxaparin Sodium is a low molecular weight heparin that:

• Binds to antithrombin III, enhancing its activity
• Inhibits Factor Xa and to a lesser extent Factor IIa (thrombin)
• Prevents formation and propagation of blood clots
• Provides predictable anticoagulant effects with a lower risk of heparin-induced thrombocytopenia (HIT) compared to unfractionated heparin

By selectively targeting Factor Xa, Vistarin effectively prevents thrombus formation while minimizing systemic side effects.

Dosage and Administration

• Administered via subcutaneous injection, typically in the abdomen
• Pre-filled syringe ensures accurate dosing of 4000 Anti-Xa IU/0.4 ml
• Frequency and duration depend on the patient’s condition, weight, and clinical indication
• Avoid intramuscular injections to reduce risk of hematoma
• Rotate injection sites to prevent skin irritation
• Monitor platelet count, renal function, and signs of bleeding during therapy

Benefits

• Prevents venous thromboembolism and pulmonary embolism
• Treats deep vein thrombosis and acute coronary syndromes
• Predictable anticoagulant effect reduces need for frequent monitoring
• Lower risk of heparin-induced thrombocytopenia (HIT) compared to unfractionated heparin
• Pre-filled syringe ensures accurate, convenient dosing

Side Effects

Common side effects may include:

• Mild injection site reactions (pain, redness, swelling)
• Minor bleeding or bruising

Serious but rare side effects:

• Major bleeding (internal or gastrointestinal)
• Heparin-induced thrombocytopenia (HIT)
• Allergic reactions (rash, swelling, difficulty breathing)

Seek immediate medical attention for severe bleeding or signs of allergic reaction.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use with caution in patients with active bleeding, severe liver or kidney disease, or low platelet count
• Avoid concurrent use with other anticoagulants unless prescribed
• Pregnancy and breastfeeding: only use under strict medical supervision
• Monitor blood counts and coagulation parameters regularly
• Do not use in patients with a history of heparin-induced thrombocytopenia (HIT)

Storage

• Store between 2°C and 8°C (refrigerated)
• Protect from light and freezing
• Keep the pre-filled syringe in its original packaging until use
• Keep out of reach of children
• Do not use after the expiration date.