Zerotil Plus Tablet 250 mg + 62.5 mg is a combination antibiotic containing Cefuroxime Axetil and Clavulanic Acid. It is designed to treat a wide range of bacterial infections, including those caused by beta-lactamase producing organisms. The addition of Clavulanic Acid enhances the effectiveness of Cefuroxime by preventing bacterial resistance, making this combination more potent in resistant infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Zerotil Plus Tablet is indicated for the treatment of:

• Respiratory tract infections (bronchitis, pneumonia, tonsillitis, sinusitis)
• Ear, nose, and throat (ENT) infections such as otitis media
• Urinary tract infections (UTIs)
• Skin and soft tissue infections
• Mixed or resistant bacterial infections
• Other infections as prescribed by a physician

Mechanism of Action

This combination works through dual antibacterial action:

• Cefuroxime Axetil: A cephalosporin antibiotic that inhibits bacterial cell wall synthesis, leading to bacterial cell death
• Clavulanic Acid: A beta-lactamase inhibitor that prevents bacteria from destroying Cefuroxime, thereby enhancing its effectiveness

Together, they provide broad-spectrum coverage and improved efficacy against resistant bacteria.

Dosage and Administration

• Dosage is determined by a physician based on infection type and severity
• Usually taken twice daily
• Best taken after food to improve absorption and reduce stomach upset
• Swallow tablet whole with water; do not crush or chew
• Complete the full prescribed course even if symptoms improve early

Benefits

• Broad-spectrum antibiotic coverage
• Effective against resistant bacterial infections
• Enhanced action due to beta-lactamase inhibition
• Helps treat respiratory, urinary, and skin infections
• Improves clinical outcomes in difficult-to-treat infections

Side Effects

Common side effects may include:

• Nausea or vomiting
• Diarrhea
• Abdominal discomfort
• Headache
• Skin rash

Serious side effects (rare):

• Allergic reactions (swelling, breathing difficulty, severe rash)
• Severe diarrhea (Clostridium difficile infection)
• Liver enzyme abnormalities
• Blood disorders (rare)

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use only under medical supervision
• Not effective against viral infections
• Use cautiously in patients with penicillin or cephalosporin allergy
• Dose adjustment may be required in kidney impairment
• Complete full course to prevent antibiotic resistance
• Inform physician about all concurrent medications

Storage

• Store below 25°C
• Protect from moisture and light
• Keep out of reach of children.