Depomed Injection 500 mg/vial contains Methylprednisolone Sodium Succinate 500 mg, a potent, water-soluble corticosteroid designed for intravenous (IV) or intramuscular (IM) administration. This formulation is intended for rapid and effective systemic anti-inflammatory and immunosuppressive therapy. Methylprednisolone sodium succinate is a short-acting glucocorticoid that provides immediate relief in severe acute conditions requiring quick intervention.

The active ingredient works by modulating the body’s immune and inflammatory responses. It suppresses the production of inflammatory mediators such as prostaglandins, leukotrienes, and cytokines, reduces capillary permeability, and limits the migration of white blood cells to sites of inflammation. These mechanisms help control swelling, redness, pain, and tissue damage. Depomed Injection 500 mg is particularly useful in emergencies or severe cases where oral corticosteroids are insufficient or impractical.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Depomed Injection 500 mg/vial is indicated for the management of severe inflammatory, allergic, and autoimmune conditions, including:

• Severe asthma attacks and acute exacerbations of chronic obstructive pulmonary disease (COPD)

• Rheumatoid arthritis, osteoarthritis, and other severe joint inflammations

• Acute flare-ups of systemic lupus erythematosus and other connective tissue disorders

• Severe allergic reactions including anaphylaxis and angioedema

• Dermatologic conditions such as severe psoriasis or eczema

• Hematologic disorders requiring corticosteroid therapy

• Shock, adrenal insufficiency, or other life-threatening inflammatory conditions

This high-dose formulation is ideal for hospitalized patients or those requiring rapid clinical improvement.

Dosage and Administration

The dosage of Depomed Injection 500 mg must be individualized based on the patient’s condition, severity, and clinical response.

• Administered only by a trained healthcare professional

• Intravenous or intramuscular injection as directed by the physician

• May be given as a single dose or in divided doses depending on clinical requirements

• Strict aseptic technique must be maintained to prevent infection

Close monitoring of vital signs and patient response is essential, especially during high-dose therapy.

Precautions

• Contraindicated in patients with hypersensitivity to corticosteroids

• Use with caution in patients with diabetes, hypertension, infections, osteoporosis, or gastrointestinal ulcers

• May suppress the immune system, increasing susceptibility to infections

• Avoid abrupt discontinuation after prolonged therapy to prevent adrenal insufficiency

• Inform the healthcare provider of any ongoing infections, recent vaccinations, or chronic medical conditions

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Fluid retention and swelling

• Increased blood sugar levels

• Mood changes, irritability, or insomnia

• Gastrointestinal discomfort

• Injection site reactions

Serious adverse effects are rare but require immediate medical attention. Seek help if severe allergic reactions, vision changes, unusual bruising, or signs of infection occur.

Storage

• Store below 25°C

• Protect from light

• Keep in a dry place

• Keep out of reach of children

Depomed Injection 500 mg/vial provides rapid and effective corticosteroid therapy for severe and acute inflammatory or allergic conditions when administered under proper medical supervision.