Ezetim Tablet 10 mg contains Ezetimibe, a lipid-lowering agent used to reduce elevated cholesterol levels in patients with hyperlipidemia or mixed dyslipidemia. Unlike statins, which act primarily in the liver, Ezetimibe selectively inhibits the intestinal absorption of cholesterol and related sterols, reducing the total amount of cholesterol delivered to the liver. This mechanism leads to decreased blood cholesterol levels and contributes to improved cardiovascular health.

Ezetimibe is often prescribed as monotherapy or in combination with statins to achieve optimal lipid control in patients who require additional cholesterol-lowering effects beyond statin therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Ezetim Tablet 10 mg is indicated for:

• Primary hypercholesterolemia (heterozygous familial and non-familial): To reduce elevated total cholesterol, LDL-cholesterol, and apolipoprotein B

• Mixed dyslipidemia: To reduce LDL cholesterol in combination with statins or other lipid-lowering therapies

• Homozygous familial hypercholesterolemia: In combination with other lipid-lowering treatments to reduce LDL-C

• Sitosterolemia (phytosterolemia): To reduce elevated plant sterol levels in patients with this rare inherited condition

Dosage and Administration

Recommended Adult Dosage:

• Standard dose: 10 mg once daily, with or without food

• Combination therapy: Can be administered with a statin or other lipid-lowering drugs as advised by a physician

• Monitoring: Regular lipid profile checks are recommended to evaluate therapeutic response

Administration Guidelines:

• Take the tablet with a glass of water

• Can be taken at any time of day, with or without food

• Adherence to therapy and lifestyle measures such as diet and exercise is essential for maximum benefit

Mechanism of Action

Ezetimibe works by inhibiting the Niemann-Pick C1-Like 1 (NPC1L1) protein in the small intestine, which is responsible for the absorption of cholesterol from the diet and bile. By blocking this pathway, Ezetimibe reduces the delivery of intestinal cholesterol to the liver. The liver responds by increasing LDL receptor activity, which removes LDL cholesterol from the bloodstream. This dual mechanism effectively lowers plasma levels of LDL-C, total cholesterol, and apolipoprotein B.

Contraindications

Ezetimibe should not be used in patients with:

• Known hypersensitivity to Ezetimibe or any component of the formulation

• Active liver disease or unexplained persistent elevations of liver enzymes (when used in combination with statins)

Side Effects

Ezetimibe is generally well tolerated. Common adverse reactions include:

• Headache

• Diarrhea or abdominal pain

• Fatigue

• Muscle pain (myalgia), especially when combined with statins

• Rarely, elevated liver enzymes may occur, particularly in combination therapy with statins

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Monitor liver function tests periodically when used with statins

• Inform your doctor about any history of gallbladder disease or liver problems

• Use caution in pregnant or breastfeeding women; therapy should only be initiated if the potential benefits outweigh risks

• Ezetimibe is not a substitute for diet, exercise, or weight control measures

Drug Interactions

• Ezetimibe may interact with bile acid sequestrants, which can reduce its absorption; separate administration by 2 hours before or 4 hours after the sequestrant is recommended

• Co-administration with fibrates may increase the risk of gallstones

• Statins may be combined safely under supervision, but monitoring for myopathy or liver toxicity is advised

Use in Special Populations

• Pediatric Use: Safety and efficacy established in children aged 10 years and older with heterozygous familial hypercholesterolemia

• Geriatric Use: No dosage adjustment needed; monitor for tolerance

• Renal Impairment: No dose adjustment required

• Hepatic Impairment: Avoid use in moderate to severe hepatic dysfunction

Storage Conditions

• Store at 20–25°C in a dry place

• Protect from light and moisture

• Keep out of reach of children

Summary

Ezetim Tablet 10 mg is a potent cholesterol absorption inhibitor that effectively lowers LDL cholesterol, total cholesterol, and apolipoprotein B. Suitable as monotherapy or in combination with statins, it supports cardiovascular health when used alongside lifestyle modifications. Regular monitoring of lipid levels and liver function ensures safe and effective long-term therapy.