Larcadip 10 mg contains Lercanidipine, a third-generation dihydropyridine calcium-channel blocker used in the treatment of mild to moderate essential hypertension. It is designed to provide effective and sustained blood pressure control with a favorable tolerability profile. Due to its high vascular selectivity, Lercanidipine lowers blood pressure primarily by relaxing blood vessels, with minimal effect on heart rate and cardiac contractility.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Calcium-Channel Blockers

Indications

Larcadip 10 mg is indicated for:

• Treatment of mild to moderate essential hypertension

• Patients requiring long-term blood pressure control with once-daily dosing

It may be used alone or in combination with other antihypertensive agents such as beta-blockers, diuretics, or ACE inhibitors when monotherapy is insufficient.

Pharmacology

Lercanidipine is a dihydropyridine calcium-channel blocker that inhibits the influx of calcium ions through slow L-type calcium channels in vascular smooth muscle during depolarization. This action results in relaxation of arterial smooth muscle and a reduction in peripheral vascular resistance, leading to decreased blood pressure.

Lercanidipine shows greater selectivity for vascular smooth muscle compared to cardiac muscle, which explains its potent antihypertensive effect without significant negative inotropic activity. Its high lipophilicity and membrane partition coefficient contribute to a prolonged and smooth antihypertensive action, allowing once-daily administration.

Dosage and Administration

Adults and Elderly:

• Recommended starting dose: 10 mg once daily

• Taken orally at least 15 minutes before meals

• Dose may be increased to 20 mg once daily depending on patient response

• Maximum antihypertensive effect may take up to 2 weeks to become fully apparent

Renal or Hepatic Impairment:

• Use with caution in mild to moderate impairment

• Doses above 20 mg daily should be approached cautiously

• Not recommended in severe renal or hepatic dysfunction

Children:

• Use is not recommended in patients under 18 years due to lack of clinical data

Administration Instructions

• Must be taken on an empty stomach

• Avoid grapefruit juice, as it can increase plasma levels of Lercanidipine

Drug Interactions

Concomitant use should be avoided with:

• Cyclosporin

• Phenytoin, carbamazepine, rifampicin

• Ketoconazole, itraconazole, ritonavir

• Erythromycin, troleandomycin, midazolam

Caution is required when used with:

• Astemizole, amiodarone, quinidine

• Cimetidine, metoprolol, simvastatin

Contraindications

Larcadip 10 mg is contraindicated in patients with:

• Left ventricular outflow tract obstruction

• Untreated congestive heart failure

• Unstable angina pectoris

• Recent myocardial infarction (within 1 month)

• Known hypersensitivity to dihydropyridines

• Concomitant intake of grapefruit juice

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Lercanidipine is generally well tolerated. Common side effects include:

• Flushing

• Peripheral edema

• Headache

• Dizziness

• Asthenia

Less common side effects may include:

• Fatigue

• Gastrointestinal disturbances (nausea, dyspepsia, diarrhea)

• Rash, somnolence, myalgia

Pregnancy and Lactation

• Pregnancy Category C

• Not recommended during pregnancy due to lack of clinical data

• Should not be used by women of childbearing potential without effective contraception

• Not recommended during lactation, as distribution into breast milk is likely

Precautions and Warnings

• Use with caution in patients with ischemic heart disease

• Special care in sick sinus syndrome or left ventricular dysfunction

• Monitor blood pressure regularly

Overdose

Overdose may cause excessive vasodilation, hypotension, and reflex tachycardia. Dialysis is unlikely to be effective due to high lipophilicity. Supportive treatment is recommended.

Storage Conditions

Store below 30°C, protected from light and moisture.
Keep out of reach of children.

Mode of Action

Lercanidipine selectively blocks calcium entry into vascular smooth muscle cells, causing vasodilation and reduced peripheral resistance. Its prolonged antihypertensive activity and lack of significant cardiac depression make it suitable for long-term hypertension management.