Temonix Capsule 100 mg contains Temozolomide, an oral alkylating chemotherapy agent used in the treatment of certain types of brain tumors. It is commonly prescribed for glioblastoma multiforme and anaplastic astrocytoma. Temozolomide works by damaging the DNA of cancer cells, thereby slowing or stopping their growth.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Temozolomide 100 mg

Mechanism of Action

Temozolomide is a prodrug that is converted in the body into an active compound, MTIC (monomethyl triazeno imidazole carboxamide). MTIC methylates DNA at the O6 and N7 positions of guanine, leading to DNA damage and inhibition of cancer cell replication. This results in tumor cell death, particularly in rapidly dividing cells.

Indications

Temonix Capsule 100 mg is indicated for:

• Glioblastoma multiforme (newly diagnosed and recurrent)
• Anaplastic astrocytoma (refractory or recurrent cases)
• Other malignant brain tumors as prescribed by an oncologist

Dosage and Administration

• Dosage must be strictly prescribed by an oncologist based on body surface area and treatment cycle.
• Taken orally once daily on an empty stomach or as directed.
• Swallow whole with a full glass of water; do not open or chew.
• Treatment is usually given in cycles with rest periods in between.
• Anti-nausea medication may be prescribed before dosing.

Benefits

• Effective oral chemotherapy for brain tumors
• Crosses the blood-brain barrier efficiently
• Can be used in combination with radiotherapy or other agents
• Improves progression-free survival in selected patients
• Convenient oral administration compared to injectable chemotherapy

Side Effects

Common side effects may include:

• Nausea and vomiting
• Fatigue
• Loss of appetite
• Headache
• Constipation

Serious side effects may include bone marrow suppression (low white blood cells, platelets, or hemoglobin), increased risk of infection, bleeding, or liver function abnormalities. Immediate medical attention is required if severe symptoms occur.

Precautions and Warnings

• Must be used only under strict oncology supervision.
• Regular blood count monitoring is essential during treatment.
• Increased risk of infections due to bone marrow suppression.
• Not recommended during pregnancy due to risk of fetal harm.
• Effective contraception should be used during and after therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Temonix Capsule may interact with:

• Valproic acid (may increase bone marrow suppression)
• Other chemotherapy agents
• Immunosuppressive medications
• Drugs affecting liver enzyme activity

Always inform your healthcare provider about all medications being used.

Storage

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children..