Uniplar Capsule 1 mcg contains Paricalcitol, a vitamin D analog used primarily to prevent and manage secondary hyperparathyroidism in patients with chronic kidney disease (CKD). Secondary hyperparathyroidism is a common complication of CKD, characterized by elevated levels of parathyroid hormone (PTH) that can lead to bone disorders, cardiovascular issues, and disturbances in mineral metabolism.

Paricalcitol works by selectively activating vitamin D receptors, which helps regulate calcium and phosphorus levels in the body while suppressing excessive PTH production. Unlike traditional vitamin D supplements, Paricalcitol minimizes the risk of hypercalcemia and hyperphosphatemia, making it a safer option for CKD patients.

Uniplar Capsule is typically prescribed under medical supervision as part of a comprehensive management plan for CKD patients, often in conjunction with dietary control and other medications.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each capsule contains:
Paricalcitol – 1 mcg

Indications

Uniplar Capsule 1 mcg is indicated for:

• Prevention and treatment of secondary hyperparathyroidism in chronic kidney disease

• Management of elevated parathyroid hormone (PTH) levels in patients undergoing dialysis

• Supporting bone and mineral metabolism in CKD patients

Mechanism of Action

Paricalcitol is a selective vitamin D receptor activator (VDRA). It binds to vitamin D receptors in the parathyroid glands and other tissues, leading to:

• Suppression of parathyroid hormone (PTH) synthesis and release

• Regulation of calcium and phosphorus metabolism

• Reduction of bone resorption caused by high PTH levels

By specifically targeting PTH without significantly raising calcium and phosphorus levels, Paricalcitol helps maintain mineral balance while preventing bone and cardiovascular complications associated with CKD.

Dosage and Administration

Uniplar Capsule should be taken strictly as prescribed by a healthcare professional:

• The usual starting dose depends on the patient’s PTH levels, kidney function, and clinical condition.

• Capsules should be taken orally with water, preferably after meals to enhance absorption.

• Dosage adjustments are made based on regular monitoring of PTH, calcium, and phosphorus levels.

• Patients should follow their doctor’s instructions carefully and not alter the dose without medical guidance.

Precautions

Before using Uniplar Capsule 1 mcg, the following precautions should be observed:

• Use with caution in patients with high calcium or phosphorus levels.

• Monitor serum calcium, phosphorus, and PTH regularly during therapy.

• Inform the doctor about any history of hypercalcemia, hyperphosphatemia, or other endocrine disorders.

• Avoid self-medication or use in combination with other vitamin D analogs unless prescribed.

• Not recommended for patients with severe hypercalcemia.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Paricalcitol is generally well tolerated, but some patients may experience:

• Nausea or vomiting

• Headache

• Fatigue

• Mild hypercalcemia

• Gastrointestinal discomfort

Severe side effects such as significant hypercalcemia are rare but require immediate medical attention.

Storage

• Store below 25°C in a cool, dry place.

• Protect from light and moisture.

• Keep out of reach of children.